About the position
This three-year PhD studies whether microproteins, very small proteins, could become a new treatment for advanced prostate cancer. You will look at how certain microproteins control SOX2, a protein that switches genes on and off, and work out the structure of the complex they form with it.
The post is in the Department of Molecular Medicine at the University of Oslo's Institute of Basic Medical Sciences, in the Collas Lab, and is funded by the Research Council of Norway. You will also work with partners at the Technical University of Denmark (DTU).
What you will do
- Plan and run genomics experiments (RNA-seq, ATAC-seq, ChIP-seq), proteomics, and the expression and purification of proteins.
- Design and carry out cell-based tests, and use crystallography to solve the structure of the SOX2–microprotein complex.
- Keep electronic lab records, analyse your data, present at meetings, help write papers, and take the required doctoral courses.
Who can apply
- A five-year master's degree, or equivalent, in molecular biology, epigenetics or a related field, with at least a B on the ECTS grading scale.
- Experience in cell and molecular biology, such as vector design, cloning, engineering cell lines and cell-based assays.
- Knowledge of chromatin, transcription regulation or microproteins, and fluent spoken and written English.
- An advantage: proteomics, bioinformatics for epigenetic data, electronic lab journals such as Benchling, or published work.
What is offered
- A three-year, full-time post as a Doctoral Research Fellow, paid NOK 550,800 to 607,500 a year depending on experience.
- From the salary, 2% goes to the State Pension Fund, which gives membership of one of Norway's best pension schemes, with good mortgage and insurance terms.
- Norwegian language courses if you do not already speak Norwegian, Swedish or Danish at A2 level.
- Up to 1.5 hours a week of exercise during working hours.
How to apply
- Apply through Jobbnorge, the University of Oslo's recruitment system, linked below. All documents must be in English or a Scandinavian language, and nothing can be added after the deadline.
- A cover letter on your research interests and motivation, and a CV entered in Jobbnorge's own CV form.
- Your academic transcripts, with an explanation of your university's grading system if you studied outside Norway.
- A list of publications (not the publications themselves), and contact details for three referees.
- Any certificate for laboratory animal work, if you have one.